uniQure: Worst Case Scenario Becomes Reality

Qure’s AMT-130 faces FDA efficacy doubts after 12-month data. QURE's upside now hinges on political pressure. Read here for ...
STAT

I tried to design a clinical trial for a supplement. 5 things got in the way

When Elise Felicione tried to design a clinical trial for a supplement, 5 things got in the way. It’s a lesson for the ...
IPM

Randomized control trial shows drinking water promotion can prevent overweight and reduce sugar-sweetened beverage intake in schoolchildren

A new study in the American Journal of Preventive Medicine reports findings from a randomized controlled trial—the gold standard study design in health research—showing that promoting drinking water ...
IEEE

Randomized Customer-Sensitivity-Aware Control of Thermostatic Loads for Better Integration of Intermittent Renewables

Abstract: Increased electric grid penetration of intermittent renewable energy sources has reduced the controllability of the generation side and created a need for more coordination between ...
IEEE

Safety-Critical Randomized Event-Triggered Learning of Gaussian Process With Applications to Data-Driven Predictive Control

Abstract: Safety and data efficiency are important concerns in data-driven control, especially for nonlinear systems with unknown dynamics and subject to disturbances. In this work, we consider a ...
Frontiers

The efficacy and safety of low-intensity focused ultrasound pulses for prolonged disorders of consciousness: a study protocol for a randomized controlled trial

Recent randomized controlled trials (RCTs) in patients with prolonged disorders of consciousness (pDoC) have yielded limited success. Among them, only studies involving amantadine have provided Class ...
ahajournals.org

Abstract 4363704: YOSEMITE Rationale and Design: Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Zodasiran Efficacy and Safety in Adolescents and Adults with ...

Methods: YOSEMITE is a phase 3, randomized, double-blind, placebo-controlled trial. Key inclusion criteria are genetically confirmed HoFH or a clinical diagnosis (total cholesterol >500 mg/dL OR ...
The New England Journal of Medicine

A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia

Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings. Whether these drugs are beneficial in low-resource settings ...
Nasdaq

Rockwell Automation Launches FactoryTalk Design Workbench, a Free Software Tool for Building Micro Control Systems Smarter and Faster

MILWAUKEE, Oct. 28, 2025 /PRNewswire/ -- Rockwell Automation, Inc. (NYSE: ROK), the world's largest company dedicated to industrial automation and digital transformation, today announced the launch of ...
SciELO

Schizophrenia TreAtment with electRic Transcranial Stimulation (STARTS): design, rationale and objectives of a randomized, double-blinded, sham-controlled trial

Introduction Schizophrenia is a severe mental disorder. While some antipsychotic medications have demonstrated efficacy in treating positive symptoms, there is no widely recognized treatment for ...
Frontiers

Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a ...

Electroconvulsive therapy (ECT) is one of the main strategies for major depressive disorder (MDD). Recently, the use of esketamine in the treatment of depression due to the rapid antidepressant ...
The New England Journal of Medicine

Ivermectin to Control Malaria — A Cluster-Randomized Trial

Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic ...