Pulmonary arterial hypertension (PAH) involves progressive cellular and molecular change within the pulmonary vasculature, leading to increased vascular resistance. Current therapies targeting nitric ...
The origin of many diseases begins at the cellular level and involves multiple molecular interactions. However, previous methods have struggled to accurately observe changes in individual cells.
Breast cancer remains one of the most prevalent and life-threatening forms of cancer, impacting millions worldwide. This malignancy's heterogeneity and complexity have long posed significant ...
Use of ultra-sensitive whole genome circulating tumor DNA detection to predict early recurrence in high-risk localized RCC after nephrectomy: Preliminary real-world findings. Forty-two genes ...
Advancements in spatial perturbation transcriptomics (SPT) have revolutionized our understanding of cellular behavior in native tissue contexts by integrating spatial and perturbation data. However, ...
aDepartment of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA bDivision of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, ...
Although containing more neurons than the rest of the brain regions combined, the cerebellum remains understudied in human development compared to the cerebral cortex. Consequently, much of our ...
Abstract: Spatial transcriptomics has revolutionized the ability to investigate transcriptional patterns within tissue morphology. However, many ST clustering pipelines operate on a single preselected ...
The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...
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