Post-translational modifications (PTMs) of tubulin, including acetylation, glutamylation and detyrosination, play a critical role in dictating the dynamic behaviour and specialised functions of ...

Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide. Additionally, about one-fourth of the world's population carries Mycobacterium ...

Built on groundbreaking research from Israel ’s Weizmann Institute of Science, Promise Bio developed the first cloud-based platform for broad epiproteomics, helping researchers uncover disease ...

Whole blood derived from six adult donors who were inoculated with BCG in their childhood was cultured with MDP1 alone, MDP1 in combination with G9.1, or in combination with the negative form of ...

Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...

A new study led by Nicolás Bologna, a CSIC researcher at the Center for Research in Agricultural Genomics (CRAG), sheds light on the crucial role of the N-terminal extension (NTE) of AGO proteins, ...

This multidisciplinary project integrates computational biology, structural modelling, population genomics, and AI. It will provide new mechanistic insights into how coding variation and PTMs ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...