Researchers have created a method called optovolution that uses light to guide the evolution of proteins with dynamic behaviors. By engineering yeast cells so their survival depended on proteins ...

The low efficiency of conventional vectors used for genetic medicines often means delivering them at high doses and by suboptimal routes, leading to inflammation, toxic side effects and limited ...

Scientists have developed a novel protein evolution approach dubbed optovolution that uses light to guide the evolution of proteins with dynamic, multi-state, and computational functions based on ...

Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

Gene therapy has experienced an increasing number of successful human clinical trials, leading to 6 FDA approved products using delivery vectors based on adeno-associated viruses (AAV). These ...

Breakthrough directed evolution system boosts virus-like particles for safer, more efficient gene editing, offering a powerful tool for next-generation therapeutic innovations. Study: Directed ...

EPFL researchers have developed a light-based method that can produce proteins that switch states, respond to signals, and even compute, using light and the cell cycle. Evolution is biology's powerful ...