For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

Artificial intelligence has just redrawn the map of our genome’s control room, revealing hundreds of thousands of tiny DNA knots that behave less like static quirks and more like hidden switches.

How does our DNA store the massive amount of information needed to build a human being? And what happens when it's stored incorrectly? Jesse Dixon, MD, Ph.D., has spent years studying the way this ...

Less than 2% of the genome codes for proteins; the rest, once called 'junk DNA', contains regulatory elements. Researchers analyzed 10,000 to reveal how variants shape gene activity.

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

Scientists at UC Berkeley have discovered a microbe that bends one of biology’s most sacred rules. Instead of treating a specific three-letter DNA code as a clear “stop” signal, this methane-producing ...

Thioguanosine (shown as S in the sequence) is placed at nearby, non-complementary positions within a DNA duplex. When exposed to light or mild oxidants, the modified bases react to form a disulfide ...